4.8 Article

Simplification of the Mitsunobu reaction.: Di-p-chlorobenzyl azodicarboxylate:: A new azodicarboxylate

Journal

ORGANIC LETTERS
Volume 8, Issue 22, Pages 5069-5072

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol0618757

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Di-p-chlorobenzyl azodicarboxylate (DCAD) is introduced as a novel, stable, solid alternative to DEAD and DIAD for a variety of Mitsunobu couplings. DCAD/Ph3P-mediated reactions in CH2Cl2 generate a readily separable hydrazine byproduct.

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