Journal
SCIENCE
Volume 314, Issue 5799, Pages 657-661Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1131794
Keywords
-
Categories
Ask authors/readers for more resources
In mammals, odorant receptors (ORs) direct the axons of olfactory sensory neurons (OSNs) toward targets in the olfactory bulb. We show that cyclic adenosine monophosphate ( cAMP) signals that regulate the expression of axon guidance molecules are essential for the OR-instructed axonal projection. Genetic manipulations of ORs, stimulatory G protein, cAMP-dependent protein kinase, and cAMP response element - binding protein shifted the axonal projection sites along the anterior-posterior axis in the olfactory bulb. Thus, it is the OR-derived cAMP signals, rather than direct action of OR molecules, that determine the target destinations of OSNs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available