4.7 Article

Gold-catalyzed and N-iodosuccinimide-mediated cyclization of γ-substituted allenamides

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 71, Issue 22, Pages 8658-8660

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo061340r

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Funding

  1. NIGMS NIH HHS [GM 54524, GM 49631] Funding Source: Medline

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Chiral gamma-substituted allenamides have been shown to undergo efficient gold-catalyzed and N-iodosuccinimide-mediated cyclization to highly functionalized dihydrofurans. These reactions proceed rapidly and without loss of stereochemistry.

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