Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 203, Issue 11, Pages 2519-2527Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20061692
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Funding
- MRC [MC_U120027516] Funding Source: UKRI
- Medical Research Council [MC_U120027516] Funding Source: researchfish
- Medical Research Council [MC_U120027516] Funding Source: Medline
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Micro RNAs (miRNAs) regulate gene expression at the posttranscriptional level. Here we show that regulatory T (T reg) cells have a miRNA profile distinct from conventional CD4 T cells. A partial T reg cell-like miRNA profile is conferred by the enforced expression of Foxp3 and, surprisingly, by the activation of conventional CD4 T cells. Depleting miRNAs by eliminating Dicer, the RNAse III enzyme that generates functional miRNAs, reduces T reg cell numbers and results in immune pathology. Dicer facilitates, in a cell-autonomous fashion, the development of T reg cells in the thymus and the efficient induction of Foxp3 by transforming growth factor beta. These results suggest that T reg cell development involves Dicer-generated RNAs.
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