Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 203, Issue 11, Pages 2409-2412Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20061754
Keywords
-
Categories
Ask authors/readers for more resources
CD40 was initially identified as a receptor expressed by B cells that is crucial for inducing an effective adaptive immune response. CD40 was subsequently shown to be expressed by endothelial cells and to promote angiogenesis. New data now show that in tumor-prone transgenic mice, CD40-mediated neovas-cularization is essential for early stage tumorigenicity. This suggests, at least in this mouse model, that CD40 has an important role in the angiogenic process that is coupled to carcinogenesis, a finding that could lead to novel therapeutic opportunities.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available