Journal
NEUROSCIENCE LETTERS
Volume 407, Issue 3, Pages 219-223Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2006.08.036
Keywords
Huntington's disease; riluzole; memantine; glutamate; calcium; apoptosis; TUNEL; transgenic mice
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Funding
- NINDS NIH HHS [R01 NS38082] Funding Source: Medline
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Huntington's disease (HD) is an autosomal dominant, inherited and fatal neurodegenerative disorder for which there is, at present, no effective treatment or cure. Striatal medium spiny neurons (MSN) are the most sensitive in HD. Dysregulation of glutamate/calcium signaling pathway emerges as a possible cause of striatal MSN neurodegeneration in HD. Here we evaluated five clinically relevant glutamate pathway inhibitors using previously developed in vitro HD model. We found that folic acid, gabapentin and lamotrigine did not protect HD neurons from glutamate-induced cell death, but memantine and riluzole were protective. Our results provide further support to potential use of memantine and riluzole for treatment of HD. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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