Journal
VACCINE
Volume 24, Issue 42-43, Pages 6534-6541Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2006.06.021
Keywords
natural antibodies; acquired antibodies; Aeromonas salmonicida
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Bovine serum albumin (BSA) and the surface A-layer protein (AP) of an atypical strain of fish bacterial pathogen Aeromonas salmonicida were covalently linked with polymeric nano- and microparticles, and antigenicity of the resulted conjugates was compared in mice and goldfish. Distinct albeit different levels of natural BSA and AP antibodies were present in both animal species. Significant stimulation of the anti-AP antibody response in mice strikingly contrasted to unresponsiveness or even suppression in fish. The results negatively correlate with the levels of respective natural antibodies in the host and are discussed in context of problems related to fish vaccination. The work reinforces the instructive role of natural antibodies in adaptive immune response. (c) 2006 Elsevier Ltd. All rights reserved.
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