Journal
FEBS LETTERS
Volume 580, Issue 25, Pages 5905-5909Publisher
WILEY
DOI: 10.1016/j.febslet.2006.08.088
Keywords
Bik; E2F; apoptosis; chemotherapy
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BH3-only proteins are required for execution of apoptotic cell death. We have found that one of these proteins, Bik, is strongly induced in cancer cells treated with chemotherapeutic agents. Furthermore, we showed that chemotherapy-induced expression of bik is independent of p53. Consistent with its pro-apoptotic activity, blockade of bik expression reduces the adriamycin-mediated apoptotic cell death. We also found that the bik gene is transcriptionally activated by E2F. proteins. Consistently, adriamycin induces the E2F-bik pathway. In addition, E2Fs transactivate bik by a p53-independent mechanism. Thus, our data indicate that transcriptional regulation of bik contributes to the efficient apoptotic response to chemotherapeutic agents. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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