Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 103, Issue 44, Pages 16568-16573Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0607822103
Keywords
cAMP response element-binding protein (CREB); phosphorylation; learning; polyphenol; natural product
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Funding
- NIA NIH HHS [R01 AG025337, AG 025337] Funding Source: Medline
- NINDS NIH HHS [NS 28121, P01 NS028121] Funding Source: Medline
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Small molecules that activate signaling pathways used by neurotrophic factors could be useful for treating CNS disorders. Here we show that the flavonoid fisetin activates ERK and induces cAMP response element-binding protein (CREB) phosphorylation in rat hippocampal slices, facilitates long-term potentiation in rat hippocampal slices, and enhances object recognition in mice. Together, these data demonstrate that the natural product fisetin can facilitate long-term memory, and therefore it may be useful for treating patients with memory disorders.
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