4.7 Article

Determination of the titanium content of human transferrin by inductively-coupled plasma-atomic-emission spectroscopy

Journal

ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 386, Issue 6, Pages 1689-1693

Publisher

SPRINGER HEIDELBERG
DOI: 10.1007/s00216-006-0740-7

Keywords

titanocene dichloride; ICP-AES; transferrin; antitumor

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We report a simple method that combines dialysis, as a purification method, with the multielement capability of ICP to determine the titanium-to-transferrin mole ratio at physiological pH, under buffer conditions. The method, by means of which titanium and transferrin are determined simultaneously, enabled us to assess the binding capacities of different titanocene complexes.

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