Journal
EUROPEAN JOURNAL OF ENDOCRINOLOGY
Volume 155, Issue 5, Pages 671-679Publisher
BIO SCIENTIFICA LTD
DOI: 10.1530/eje.1.02277
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Type 2 diabetes is primarily associated with insulin resistance and beta-cell dysfunction. Maintenance of functional mature beta-cells is imperative for ensuring glucose homeostasis. This can be achieved by optimal expression of key transcription factors that are required for normal pancreatic development and maintaining beta-cell function. Defining the regulation of transcription factors as well as their regulation of important beta-cell genes like insulin will provide further insight into elucidating the mechanisms leading to beta-cell dysfunction.
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