Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 100, Issue 11, Pages 1858-1860Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2006.07.006
Keywords
gold(I) complex; vitamin K-3; X-ray structure; antitumoral activity
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Reaction of the vitamin K-3 derivative menadione sodium bisulfite thiosemicarbazone (NaK3TSC) with chloro(triethylphosphine)gold(I) afforded the complex [AuPEt3(K3TSC)]. This compound consists of discrete molecules in which the metal is almost linearly coordinated to P and S. Preliminary in vitro screening showed significant anti-cancer activity, notably against the cisplatin-resistant cell line A2780cis. (c) 2006 Elsevier Inc. All rights reserved.
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