Journal
HETEROCYCLES
Volume 68, Issue 11, Pages 2327-2333Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/COM-06-10856
Keywords
L-proline; aldol condensation; isatin; asymmetric catalyst
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L-proline-catalyzed asymmetric aldol condensation of several isatin derivatives with acetone is reported. The desired products were obtained in highly yield with the ee among 30-79%. The substitutes of N can deeply effect the ee value of products, and a novel mechanism is also described.
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