Journal
JOURNAL OF DERMATOLOGICAL SCIENCE
Volume 44, Issue 2, Pages 63-72Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jdermsci.2006.07.004
Keywords
citrulline; deimination; epidermis; filaggrin; hair follicles; hydration; peptidylarginine deiminases; post-translational modifications; skin
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Deimination corresponds to the transformation of arginine residues within a peptide sequence into citrulline residues. Catalyzed by peptidylarginine deiminases, it decreases the net positive charge of proteins, alters intra and intermolecular ionic interactions and probably the folding of target proteins. Deimination has recently been implicated in several physiological and pathological processes. Here, we describe the enzymes involved in this post-transtational modification, focusing on their expression, location and roles in skin, as well as their known protein substrates in the epidermis and hair follicles. We discuss also the potential involvement of deimination in human diseases including cutaneous disorders. (c) 2006 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.
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