Journal
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Volume 75, Issue 5, Pages 851-857Publisher
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.2006.75.851
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Funding
- NCRR NIH HHS [RR-02558] Funding Source: Medline
- NIAID NIH HHS [AI52781, N01-AI-25466] Funding Source: Medline
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Cryptosporidium hominis causes diarrhea in humans and has been associated with community outbreaks. This study describes the infectivity, illness, and serologic response after experimental challenge of 21 healthy adult volunteers with 10-500 C. hominis (TU502) oocysts. Sixteen subjects (76.2%) had evidence of infection; the 50% infectious dose (ID,,) was estimated to be 10-83 oocysts using clinical and microbiologic definitions of infection, respectively. Diarrhea occurred in 40% of subjects receiving 10 oocysts with a stepwise increase to 75% in those receiving 500 oocysts. A serum IgG response was seen in those receiving more than 30 oocysts. Greatest responses were seen in volunteers with diarrhea and oocyst shedding. Volunteers with no evidence of infection had indeterminant or negative IgG responses. Cryptosporidium hominis is infectious for healthy adults (ID50 = 1.0 oocysts) and is clinically similar to C. parvum-induced illness. In contrast to C. parvum, C. hominis elicted a serum IgG response in most infected persons.
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