Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 27, Issue 11, Pages 574-579Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2006.09.007
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Funding
- MRC [G9629038] Funding Source: UKRI
- Medical Research Council [G9629038] Funding Source: researchfish
- Medical Research Council [G9629038] Funding Source: Medline
- Wellcome Trust [059917] Funding Source: Medline
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Schizophrenia is a grave psychiatric disorder with psychotic symptoms and an enigmatic etiology. Family studies have strongly indicated that genetic risk factors have a role in this disease. Recent findings, together with previously established evidence, highlight the PDZ-domain-containing protein interacting with C-kinase 1 (PICK1) as a promising candidate for a schizophrenia susceptibility gene. Here, we outline possible molecular mechanisms, discuss clinical case-studies that indicate an unexpected role of PICK1 in schizophrenia and discuss potential avenues for pharmacological manipulation of PICK1.
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