Journal
JOURNAL OF IMMUNOLOGY
Volume 177, Issue 9, Pages 6018-6024Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.177.9.6018
Keywords
-
Categories
Funding
- NCI NIH HHS [CA 52527, CA 84232, CA 115880] Funding Source: Medline
- NIGMS NIH HHS [GM 08663] Funding Source: Medline
Ask authors/readers for more resources
The activation of naive CD8(+) T cells has been attributed to two mechanisms: cross-priming and direct priming. Cross-priming and direct priming differ in the source of Ag and in the cell that presents the Ag to the responding CD8(+) T cells. In cross-priming, exogenous Ag is acquired by professional APCs, such as dendritic cells (DC), which process the Ag into peptides that are subsequently presented. In direct priming, the APCs, which may or may not be DC, synthesize and process the Ag and present it themselves to CD8(+) T cells. In this study, we demonstrate that naive CD8(+) T cells are activated by a third mechanism, called cross-dressing. In cross-dressing, DC directly acquire MHC class I-peptide complexes from dead, but not live, donor cells by a cell contact-mediated mechanism, and present the intact complexes to naive CD8(+) T cells. Such DC are cross-dressed because they are wearing peptide-MHC complexes generated by other cells. CD8(+) T cells activated by cross-dressing are restricted to the MHC class I genotype of the donor cells and are specific for peptides generated by the donor cells. In vivo studies demonstrate that optimal priming of CD8(+) T cells requires both cross-priming and cross-dressing. Thus, cross-dressing may be an important mechanism by which DC prime naive CD8(+) T cells and may explain how CD8(+) T cells are primed to Ags that are inefficiently cross-presented.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available