Journal
JOURNAL OF NEURAL TRANSMISSION
Volume 113, Issue 11, Pages 1709-1715Publisher
SPRINGER WIEN
DOI: 10.1007/s00702-006-0479-5
Keywords
astrocytes; TNF alpha; S100B; GFAP; Alzheimer's disease
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Neurodegenerative disorders such as Alzheimer's disease are characterized by increased intracellular and extracellular concentrations of the astrocytic proteins glial fibrillary acidic protein (GFAP) and S100B. The present study examined the potential contribution of tumor necrosis factor alpha (TNF alpha) to these changes by measuring astrocyte viability along with the intracellular and extracellular expression of GFAP and S100B following exposure to this cytokine. Although TNF alpha did not affect astrocyte viability, the extracellular levels of both proteins were increased three-fold with associated reductions in immunocytochemical labeling.
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