Journal
NATURE NEUROSCIENCE
Volume 9, Issue 11, Pages 1362-1363Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1780
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Funding
- NIMH NIH HHS [R01 MH067602, MH64625, MH072837, K24 MH064625, MH067602, R01 MH079164] Funding Source: Medline
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We examined the contribution of 5-HT1A autoreceptors ( with [ C-11] WAY100635 positron emission tomography) to amygdala reactivity ( with blood oxygenation level - dependent functional magnetic resonance imaging) in 20 healthy adult volunteers. We found a significant inverse relationship wherein 5-HT1A autoreceptor density predicted a notable 30 - 44% of the variability in amygdala reactivity. Our data suggest a potential molecular mechanism by which a reduced capacity for negative feedback regulation of 5-HT release is associated with increased amygdala reactivity.
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