Journal
AUTOIMMUNITY REVIEWS
Volume 6, Issue 1, Pages 5-9Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autrev.2006.03.002
Keywords
TT virus; pathogenesis; autoimmunity; rheumatic disorders
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Funding
- FIC NIH HHS [F05 TW05421] Funding Source: Medline
- NIAID NIH HHS [R01 AI48079] Funding Source: Medline
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Pathogenesis of viral origin has long been suggested in autoimmune rheumatic diseases. Beside the well-defined virus induced transient or chronic rheumatic diseases often resembling systemic autoimmune disorders such as rheumatoid arthritis, viruses can contribute to disease pathogenesis by several different pathomechanisms. TT virus is a recently discovered virus of extremely high genetic diversity which commonly infects humans. Despite accumulated evidence on the biological characteristics of TTV, its pathogenecity is still in question; many consider TTV as harmless endosymbiont. The recent paper overviews the biology of TT virus and investigates the hypothesis that TTV might have a causative role in human diseases with special attention to the possibility that TTV might trigger autoimmunity in rheumatic disorders (c) 2006 Elsevier B.V. All rights reserved.
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