Journal
ENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH
Volume 13, Issue 6, Pages 375-384Publisher
INFORMA HEALTHCARE
DOI: 10.1080/10623320601061599
Keywords
endothelial cells; ERK5; KLF-2; PECAM-1; shear tress
Categories
Funding
- NHLBI NIH HHS [HL64839] Funding Source: Medline
Ask authors/readers for more resources
The focal development of atherosclerosis in the vascular tree may be explained in part by the local nature of blood flow. Bifurcations and branching points, prone to early atherogenesis, experience disturbed and oscillatory flow, whereas straight vascular regions, resistant to atherosclerosis, are exposed to steady laminar flow. A large number of studies suggest that the antiatherosclerotic effects of laminar flow are in part due to the ability of flow to modulate endothelial cell phenotype. Under steady laminar flow, endothelial cells generate molecules that promote a vasoactive, anticoagulant, anti-inflammatory, and growth - inhibitory surface. In contrast, disturbed How induces a proliferative, prothrombotic, and adhesive phenotype. Endothelial cells are able to sense the variations of flow via mechanosensitive cell surface proteins and to transduce these signals via intracellular pathways to transcription factors in the nucleus leading to phenotypic changes. This review summarizes the outside-in signaling events initiated by flow that modulate endothelial cell phenotype.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available