Journal
JOURNAL OF CEREAL SCIENCE
Volume 44, Issue 3, Pages 368-371Publisher
ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jcs.2006.10.002
Keywords
coeliac disease; germination; cereals; proteases
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We report the isolation and characterisation of proteases from germinated wheat, rye and barley, and their ability to degrade gliadin peptides toxic for coeliac patients. It is shown for the first time that these proteases cleave these peptides rapidly into non-toxic fragments with less than nine amino acids. These proteases have distinct advantages when compared to bacterial or fungal proteases, and are promising candidates for the detoxification of gluten containing foods and for oral therapy for celiac patients. (c) 2006 Elsevier Ltd. All rights reserved.
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