Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 34, Issue -, Pages 931-935Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0340931
Keywords
alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor (AMPAR); allosteric protein; calcium sensor; protein that interacts with protein C-kinase 1 (PICK1); synapse
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Funding
- Wellcome Trust Funding Source: Medline
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AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptor trafficking is a fundamental mechanism for regulating synaptic strength, and hence may underlie cellular processes involved in learning and memory. PICK1 (protein that interacts with protein C-kinase) has recently emerged as a key regulator cif AMPAR (AMPA receptor) traffic, and the precise molecular mechanisms of PICK1's action are just beginning to be unravelled. in this review, I summarize recent findings that describe some important molecular characteristics of PICK1 with respect to AMPAR cell biology.
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