Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 13, Issue 11, Pages 1031-1032Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb1163
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ESCRT-II, a complex that sorts ubiquitinated membrane proteins to lysosomes, localizes to endosomes through interaction between the Vps36 subunit's GLUE domain and phosphatidylinositides (PIs). In yeast, a ubiquitin (Ub) i nteracting NZF domain is inserted in Vps36 GLUE, whereas its mammalian counterpart, Eap45 GLUE, lacks the NZF domain. In the Eap45 GLUE - Ub complex structure, Ub binds far from the proposed PI- binding site of Eap45 GLUE, suggesting their independent binding.
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