Journal
JOURNAL OF VIRAL HEPATITIS
Volume 13, Issue 11, Pages 742-745Publisher
BLACKWELL PUBLISHING
DOI: 10.1111/j.1365-2893.2006.00759.x
Keywords
hepatitis E; rhesus monkeys; sequence comparisons; transmission
Ask authors/readers for more resources
In contrast to countries reporting zoonotic spread of hepatitis E virus (HEV), distinct genotypes circulate in humans (genotype 1) and pigs (genotype 4) from India indicating rarity of such spread. Pigs were refractory to human HEV. As rhesus is an excellent animal model for human HEV, an attempt was made to infect rhesus monkeys with swine HEV. Experimental infection of both the rhesus monkeys with swine-HEV as evidenced by seroconversion to anti-HEV antibodies and presence of viraemia suggests possibility of human infections or differential susceptibility. Comparison of Open Reading Frame-2 and hypervariable regions of HEV genomes showed identity of swine and monkey-derived HEV.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available