Journal
JOURNAL OF VIROLOGY
Volume 80, Issue 21, Pages 10874-10878Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00767-06
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Funding
- NCI NIH HHS [CA76445, R01 CA076445] Funding Source: Medline
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Human herpesvirus 8 (HHV-8) viral interleukin-6 (vlL-6) mediates signaling through the gp130 signal transducer but unlike human IL-6 (hIL-6) does not require the nonsignaling gp80 alpha subunit of the IL-6 receptor complex. By utilizing a gp80-refractory vIL-6 variant, vIL-6(R189L), we found that signal transduction, as measured by STAT1. and STAT3 activation and gp130 tyrosine phosphorylation in gp80(+)/gp130(+) HEK293T cells, was modulated by gp80. Furthermore, the signaling and BAF-130 cell growth-promoting activities of vIL-6 and hIL-6 could be distinguished, and exogenous addition of soluble gp80 enhanced cell growth supported by vIL-6. Our findings demonstrate that gp80 can modulate vIL-6 activity and that vIL-6 and hIL-6 signaling are not directly equivalent.
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