Journal
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
Volume 32, Issue 10, Pages 1199-1206Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/03639040600751886
Keywords
simvastatin; local delivery; osteogenesis; granules; gel; in vitro release
Categories
Ask authors/readers for more resources
Simvastatin (SVS), a cholesterol-lowering drug, has been shown to stimulate bone formation. This study deals with the design and in vitro evaluation of local delivery systems for simvastatin. They are intended to treat bony defects resulting from periodontitis or to induce osteogenesis around the titanium implants. Granules and gels were formulated using bioerodible/biocompatible polymers, namely hydroxypropylmethyl cellulose ( H), sodium carboxymethyl cellulose ( C), and chitosan (Ch). The in vitro release profiles and kinetics were evaluated and the swelling and/or erosion was monitored. Differential scanning calorimetry (DSC) and infrared (IR) were used to detect any SVS/polymer interactions that may affect drug release. The results revealed variable extents of controlled drug release from the designed formulae depending on the polymer nature. About 50% cumulative SVS was released from both H granules and gel formulae within 24 h and similar to 66% and similar to 88% from C granules and gel, respectively. Ch formulae exhibited similar to 50% release from granules and similar to 30% from gel.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available