Journal
BIOTECHNOLOGY LETTERS
Volume 28, Issue 22, Pages 1811-1815Publisher
SPRINGER
DOI: 10.1007/s10529-006-9157-9
Keywords
adsorbent resin; fermentation; pristinamycin; separation; Streptomyces pristinaespiralis
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Batch fermentation by Streptomyces pristinaespiralis with the addition of adsorbent resins was used to increase the production of pristinamycin. In consideration of the adsorption capacity and the desorption ability, a polymeric resin, JD-1, was finally selected. The maximum production of pristinamycin in Erlenmeyer flasks went up to 1.13 from 0.4 g l(-1), by adding 12% (w/v) resin JD-1 into the culture broth at 20 h after inoculation. In a 3 l bioreactor, pristinamycin fermentation with the addition of 12% (w/v) resin JD-1 at 20 h after inoculation reached 0.8 g l(-1), which was a 1.25-fold increase over fermentation without resin.
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