Journal
APPLIED OPTICS
Volume 45, Issue 31, Pages 8142-8151Publisher
OPTICAL SOC AMER
DOI: 10.1364/AO.45.008142
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Funding
- NCRR NIH HHS [P41 RR14075] Funding Source: Medline
- NIBIB NIH HHS [R01-EB001954, R01 EB001954-06, R01 EB001954, R01-EB002482] Funding Source: Medline
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Although most current diffuse optical brain imaging systems use only nearest-neighbor measurement geometry, the spatial resolution and quantitative accuracy of the imaging can be improved through the collection of overlapping sets of measurements. A continuous-wave diffuse optical imaging system that combines frequency encoding with time-division multiplexing to facilitate overlapping measurements of brain activation is described. Phantom measurements to confirm the expected improvement in spatial resolution and quantitative accuracy are presented. Experimental results showing the application of this instrument for imaging human brain activation are also presented. The observed improvement in spatial resolution is confirmed by functional magnetic resonance imaging. (c) 2006 Optical Society of America.
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