Journal
HUMAN IMMUNOLOGY
Volume 67, Issue 11, Pages 863-873Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.humimm.2006.08.292
Keywords
CD56(+) T cells; natural killer cells; cytokines; cytotoxicity; kinetics
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A subset of human T lymphocytes expresses the natural killer (NK) cell-associated receptor CD56 and is capable of major histocompatibility complex (MHC)-unrestricted cytotoxicity against a variety of autologous and allogeneic tumor cells. CD56(+) T cells have shown potential for immunotherapy as antitumor cytotoxic effectors, but their capacity to control adaptive immune responses via cytokine secretion is unclear. We have examined the inducibility of CD56(+) T cells from human blood in vitro and compared the kinetics of Th1, Th2, and regulatory cytokine secretion by CD56(+) T cells with those of conventional CD56 T cells. CD56 was induced on CD8(+) and CD4(-)CD8(-) T cells by CD3/T-cell receptor (TCR)-mediated activation, particularly when grown in the presence of interleukin (IL)-2. Activation-induced CD56(+) T cells proliferated less vigorously but displayed enhanced natural cytotoxicity compared with CD56(-) T cells. CD56(+) T cells released interferon-gamma (IFN-gamma) and intetleukin-13 (IL-13), but not IL-10, upon TCR stimulation. Flow cytometric analysis demonstrated that compared with CD56 T cells, elevated proportions of CD56 T cells expressed IFN-gamma, IL-4, and IL-13 within hours of activation. These acquired cytolytic and cytokine secretion activities of CD56 T cells make them potential targets for immunotherapy for infectious and immune-mediated disease.
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