Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 135, Issue 3, Pages 352-354Publisher
WILEY
DOI: 10.1111/j.1365-2141.2006.06286.x
Keywords
trisomy 21; ETV6/RUNX1; childhood; acute lymphoblastic leukaemia
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Trisomy 21 is common in ETV6/RUNX1-positive acute lymphoblastic leukaemia (ALL); both these aberrations are associated with a favourable outcome. The prognostic impact of +21 as a sole cytogenetic change could be due to a cryptic t(12;21)(p13;q22). The occurrence of ETV6/RUNX1 was determined in 66 childhood ALLs with an acquired +21 and a chromosome number < 51. ETV6/RUNX1 was found in 45% of cases and in the majority (10/18; 56%) of ALLs with sole +21. Event-free survival did not differ between the t(12;21)-positive and -negative cases. Thus, the prognostic impact of +21 is not attributable to cryptic ETV6/RUNX1.
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