Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 63, Issue 22, Pages 2626-2641Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-006-6169-5
Keywords
ancuploid neuron; chromosome loss and gain; cancer; Alzheimer's disease; ataxia telangiectasia; schizophrenia; mosaic variegated aneuploidy; Down syndrome
Categories
Funding
- NIMH NIH HHS [MH01723, MH076145] Funding Source: Medline
Ask authors/readers for more resources
The brain is remarkable for its complex organization and functions, which have been historically assumed to arise from cells with identical genomes. However, recent studies have shown that the brain is in fact a complex genetic mosaic of aneuploid and euploid cells. The precise function of neural aneuploidy and mosaicism are currently being examined on multiple fronts that include contributions to cellular diversity, cellular signaling and diseases of the central nervous system (CNS). Constitutive aneuploidy in genetic diseases has proven roles in brain dysfunction, as observed in Down syndrome (trisomy 21) and mosaic variegated aneuploidy. The existence of aneuploid cells within normal individuals raises the possibility that these cells might have distinct functions in the normal and diseased brain, the latter contributing to sporadic CNS disorders including cancer. Here we review what is known about neural aneuploidy, and offer speculations on its role in diseases of the brain.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available