Journal
BRAIN
Volume 129, Issue -, Pages 2823-2839Publisher
OXFORD UNIV PRESS
DOI: 10.1093/brain/awl251
Keywords
A beta amyloid pathway; Alzheimer's disease; amyloid beta precursor protein
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It is now 100 years since the nosological definition of Alzheimer's disease emerged. In the first 80 years, very little progress was made in understanding the mechanisms that caused the brain to degenerate in a remarkably specific fashion (amyloid accumulation with neurofibrillary changes). Over the past 20 years, there has been an explosion of knowledge which continues today at an exponential rate. The molecular pathways underlying the synaptic dysfunction in Alzheimer's disease have delivered many validated therapeutic and diagnostic targets. A variety of therapeutic strategies aimed at disease modification are now in clinical development.
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