Journal
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Volume 118, Issue 5, Pages S17-S61Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2006.09.005
Keywords
acute bacterial rhinosinusitis; chronic rhinosinusitis with or without polyps; allergic fungal rhinosinusitis; clinical trials
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Rhinosinusitis Initiative was developed by 5 national clinical research and patient care and provides templates for societies. The current guidance document is an expansion of the clinical trials in antimicrobial, anti-inflammatory, and 2004 publication Rhinosinusitis: Establishing definitions for symptom-relieving therapies for the following: (1) acute presumed bacterial rhinosinusitis, (2) chronic rhinosinusitis (CRS) without nasal polyps, (3) CRS with nasal polyps, and (4) classic allergic fungal rhinosinusitis. In addition to the templates for clinical trials and proposed study designs, the Rhinosinusitis Initiative has developed 6 appendices, which address (1) health outcomes, (2) nasal endoscopy and staging of CRS, (3) radiologic imaging, (4) microbiology, (5) laboratory measures, and (6) biostatistical methods.
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