Journal
FEBS JOURNAL
Volume 273, Issue 21, Pages 4807-4816Publisher
WILEY
DOI: 10.1111/j.1742-4658.2006.05502.x
Keywords
CAPER; PUF60; RNA splicing; U2AF
Categories
Funding
- Fundação para a Ciência e a Tecnologia [POCTI/MGI/49430/2002] Funding Source: FCT
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U2 snRNP auxiliary factor (U2AF) is an essential heterodimeric splicing factor composed of two subunits, U2AF(65) and U2AF(35). During the past few years, a number of proteins related to both U2AF(65) and U2AF(35) have been discovered. Here, we review the conserved structural features that characterize the U2AF protein families and their evolutionary emergence. We perform a comprehensive database search designed to identify U2AF protein isoforms produced by alternative splicing, and we discuss the potential implications of U2AF protein diversity for splicing regulation.
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