Journal
STEM CELLS
Volume 24, Issue 11, Pages 2428-2436Publisher
WILEY
DOI: 10.1634/stemcells.2006-0089
Keywords
mesenchymal stem cell; hematopoietic stem cell; platelet-derived growth factor; bone marrow organ system
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Funding
- Intramural NIH HHS Funding Source: Medline
- NHLBI NIH HHS [R01 HL61589, R01 HL061589] Funding Source: Medline
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Bone marrow-derived mesenchymal stem cells (BMMSCs) are multipotent postnatal stem cells that have been used for the treatment of bone defects and graft-versus-host diseases in clinics. In this study, we found that subcutaneously transplanted human BMMSCs are capable of organizing hematopoietic progenitors of recipient origin. These hematopoietic cells expressed multiple lineages of hematopoietic cell associated markers and were able to rescue lethally irradiated mice, with successful engraftment in the recipient, suggesting a potential bone marrow (BM) resource for stem cell therapies. Furthermore, we found that platelet-derived growth factor (PDGF) promotes the formation of BMMSC-generated BM niches through upregulation of beta-catenin, implying that the PDGF pathway contributes to the formation of ectopic BM. These results indicate that the BMMSC-organized BM niche system represents a unique hematopoietic progenitor resource possessing potential clinical value.
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