Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 50, Issue 11, Pages 3963-3965Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00393-06
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Funding
- NIAID NIH HHS [AI050438-04S1, R01 AI050438, R01 AI042159, AI050438, AI42159] Funding Source: Medline
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In an established Candida albicans murine keratitis model, combination therapy with ophthalmic preparations of fluconazole and cyclosporine A (CsA) demonstrated in vivo drug synergy and effectively resolved wild-type C. albicans infection more rapidly than monotherapy with either drug. Calcineurin, the target of CsA, was also found to contribute to pathogenicity.
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