Journal
CYTOKINE
Volume 36, Issue 3-4, Pages 173-179Publisher
ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2006.12.001
Keywords
measles vaccine; HLA; interleukin-2; interleukin-10; interleukin-12p40; ELISA
Funding
- NCRR NIH HHS [M01 RR000585, M01 RR00585] Funding Source: Medline
- NIAID NIH HHS [R01 AI048793-06, R01 AI033144, AI 33144, R01 AI048793, R37 AI048793, AI 48793, R01 AI033144-13] Funding Source: Medline
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HLA class I and class II associations were examined in relation to measles virus-specific cytokine responses in 339 healthy children who had received two doses of live attenuated measles vaccine. Multivariate linear regression modeling analysis revealed suggestions of associations between the expression of DPA1*0201 (p = 0.03) and DPA1*0202 (p = 0.09) alleles and interleukin-2 (IL-2) cytokine production (global p-value 0.06). Importantly, cytokine production and DQB1 allele associations (global p-value 0.04) revealed that the alleles with the strongest association with IL-10 secretion were DQB1*0302 (p = 0.02), DQB1*0303 (p = 0.07) and DQB1*0502 (p = 0.06). Measles-specific IL-10 secretion associations approached significance with DRB1 and DQA1 loci (both global p-values 0.08). Specifically, suggestive associations were found between DRB1*0701 (p=0.07), DRB1*1103 (p=0.06), DRB1*1302 (p = 0.08), DRB1*1303 (p = 0.06), DQA1*0101 (p = 0.08), and DQA1*0201 (p = 0.04) alleles and measles-induced IL-10 secretion. Further, suggestive association was observed between specific DQA1*0505 (p = 0.002) alleles and measles-specific IL-12p40 secretion (global p-value 0.09) indicating that cytokine responses to measles antigens are predominantly influenced by FILA class II genes. We found no associations between any of the alleles of HLA A, B, and Cw loci and cytokine secretion. These novel findings suggest that FILA class II genes may influence the level of cytokine production in the adaptive immune responses to measles vaccine. (c) 2006 Elsevier Ltd. All rights reserved.
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