Journal
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
Volume 6, Issue 6, Pages 879-890Publisher
TAYLOR & FRANCIS AS
DOI: 10.1586/14737159.6.6.879
Keywords
glioma; macrophages; optical nanocrystals; optical spectroscopy; surgical navigation
Categories
Ask authors/readers for more resources
The surgical management of brain tumors requires the precise localization of tumor tissues within normal brain parenchyma in order to achieve accurate diagnostic biopsy and complete surgical resection. Quantum dots are optical semiconductor nanocrystals that exhibit stable, bright fluorescence. The intravenous injection of quantum dots is accompanied by reticuloendothelial system and macrophage sequestration. Macrophages infiltrate brain tumors and phagocytize intravenously injected quantum dots, optically labeling the tumors. Macrophage-mediated delivery of quantum dots to brain tumors may represent a novel technique to label tumors preoperatively. Quantum dots within tumors may be detected with optical imaging and optical spectroscopy tools, providing the surgeon with real-time optical feedback during the resection and biopsy of brain tumors.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available