Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 50, Issue 11, Pages 3920-3922Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00223-06
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We have isolated the aph(3)-Ic gene, encoding an aminoglycoside 3-O-phosphotransferase [APH(3)-Ic], from a genomic library of an environmental Mycobacterium fortuitum strain, selecting for streptomycin resistance. APH(3)-Ic phosphorylates and inactivates streptomycin. Similar genes have been described in Streptomyces griseus and plasmid RSF1010. It is also present in some M. fortuitum clinical isolates.
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