Journal
PHYTOTHERAPY RESEARCH
Volume 20, Issue 11, Pages 945-948Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/ptr.1982
Keywords
Cimicifuga foetida; cycloartane-type triterpenoid; anticomplement activity; cimilactone A
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A tetranor-cycloartane glycoside and two 9,19-cycloartane glycosides were isolated from the EtOAc-soluble fraction of the rhizome of Cimicifuga foetida. The structures of the compounds were determined to be cimilactone A (1), 25-O-acetylcimigenol 3-O-beta-D-xylopyranoside (2) and cimigenol 3-O-alpha-L-arabinopyranoside (3), respectively, using spectroscopic analysis. The three compounds were examined for their anticomplement activity against the classical pathway of the complement system. Compound 1 showed significant anticomplement activity with an IC50 value of 28.6 mu m, whereas compounds 2 and 3 were inactive. Copyright (c) 2006 John Wiley & Sons, Ltd.
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