Journal
MEDICAL PHYSICS
Volume 33, Issue 11, Pages 4423-4430Publisher
WILEY
DOI: 10.1118/1.2361077
Keywords
deformable registration; 4DCT; 4D radiotherapy; organ motion
Funding
- PHS HHS [P01 21239] Funding Source: Medline
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Four-dimensional radiotherapy requires deformable registration to track delivered dose across varying anatomical states. Deformable registration based on B-splines was implemented to register 4D computed tomography data to a reference respiratory phase. To assess registration performance, anatomical landmarks were selected across ten respiratory phases in five patients. These point landmarks were transformed according to global registration parameters between different respiratory phases. Registration uncertainties were computed by subtraction of transformed and reference landmark positions. The selection of appropriate registration masks to separate independently moving anatomical subunits is crucial to registration performance. The average registration error for five landmarks for each of five patients was 2.1 mm. This level of accuracy is acceptable for most radiotherapy applications. (c) 2006 American Association of Physicists in Medicine.
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