Journal
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume 29, Issue 11, Pages 2304-2306Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.29.2304
Keywords
Anemarrhena asphodeloides; sarsasapogenin; antidepressant activity; forced swimming; monoamine; monoamine oxidase
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The aim of this study was to investigate the effects of sarsasapogenin from Anemarrhena asphodeloides BUNGS (Liliaceae) on the forced swimming test, and the central noradrenergic, dopaminergic and serotonergic activities in mice. Our results showed that sarsasapogenin treatment at 12.5, 25 and 50 mg/kg (p.o.) for 14 d significantly reduced the duration of immobility in the forced swimming test. These doses that affected the immobile response did not affect locomotor activity. In addition, the neurochemical assays showed that sarsasapogenin produced a marked increase of noradrenaline and serotonin levels at 50 mg/kg in both the hypothalamus and the hippocampus. Moreover, sarsasapogenin showed a monoamine oxidase inhibitory activity in the mouse brain. These findings suggest that the antidepressant activity of sarsasapogenin may involve the central monoaminergic neurotransmitter systems.
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