Journal
JOURNAL OF BACTERIOLOGY
Volume 188, Issue 21, Pages 7512-7520Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.00980-06
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Funding
- NCRR NIH HHS [P20 RR016463, 2 P20 RR016463] Funding Source: Medline
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Previously, using a chromosomal reversion assay system, we established that an adaptive mutagenic process occurs in nongrowing Bacillus subtilis cells under stress, and we demonstrated that multiple mechanisms are involved in generating these mutations (41, 43). In an attempt to delineate how these mutations are generated, we began an investigation into whether or not transcription and transcription-associated proteins influence adaptive mutagenesis. In B. subtilis, the Mfd protein (transcription repair coupling factor) facilitates removal of RNA polymerase stalled at transcriptional blockages and recruitment of repair proteins to DNA lesions on the transcribed strand. Here we demonstrate that the loss of Mfd has a depressive effect on stationary-phase mutagenesis. An association between Mfd mutagenesis and aspects of transcription is discussed.
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