Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 11, Issue 6, Pages -Publisher
SPIE-INT SOCIETY OPTICAL ENGINEERING
DOI: 10.1117/1.2400233
Keywords
Raman spectroscopy; fiber optic probes; tissues; bones; scattering
Funding
- NIAMS NIH HHS [P30 AR46024] Funding Source: Medline
- NIGMS NIH HHS [T32 GM145304] Funding Source: Medline
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Transcutaneous bone Raman spectroscopy with an exciting annulus of 785-nm laser light surrounding the field of view of a circular array of collection fibers is demonstrated. The configuration provides distributed laser light. The annulus is located 2 to 3 mm beyond the edge of the field of view of the collection fibers to reject contributions from skin and other overlying tissues. Data are presented for rat and chicken tissue. For rat tibia, the carbonate/phosphate ratio measured at a depth of 1 mm below the skin is in error by 2.3% at an integration time of 120 s and within 10% at a 30-s integration time. For chicken tibia 4 mm below the skin surface, the error is less than 8% with a 120-s integration time. (c) 2006 Society of Photo-Optical Instrumentation Engineers.
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