Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 36, Issue 11, Pages 2837-2843Publisher
WILEY
DOI: 10.1002/eji.200536618
Keywords
anergy; NFAT transcription factors; Treg; tolerance
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The Ca++-regulated calcineurin/NFAT cascade is one of the crucial signalling pathways that controls adaptive immunity. However, a number of novel experimental data suggest that, in addition to their role in T cell activation, NFATc transcription factors play also a decisive role in the generation of peripheral tolerance against self-antigens. This function of NFATc factors is mediated by controlling activation-induced cell death and clonal anergy of T helper cells and the activity of regulatory T cells. The multi-functional role of NFAR proteins characterize these transcription factors as key regulators of immunological tolerance and, if dysregulated, of development of autoimmune diseases.
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