Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Volume 1762, Issue 11-12, Pages 973-985Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbadis.2006.08.001
Keywords
complex disease; complex genetic; amyotrophic lateral sclerosis; sporadic; association study; gene; genetic
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In complex diseases like ALS, there are multiple genetic and environmental factors all contributing to disease liability. The genetic factors causing susceptibility to developing ALS can be considered a spectrum from single genes with large effect sizes causing classical Mendelian ALS, to genes of smaller effect, producing apparently sporadic disease. We examine the statistical genetic principles that underpin this model and review what is known about ALS as a disease with complex genetics. (c) 2006 Published by Elsevier B.V.
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