Journal
TOPICS IN CATALYSIS
Volume 40, Issue 1-4, Pages 35-44Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11244-006-0106-6
Keywords
aminoacylase; asymmetric catalysis; cascade reaction; hydrogenation; immobilisation
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The combination of immobilised Rh-MonoPhos (5-AlTUD-1) and Acylase I afforded a chemo-enzymatic one-pot process for the enantioselective synthesis of amino acids in water, without the need for isolation of intermediates. In addition, the enzymatic hydrolysis increases the enantiopurity of the product from 95% ee to > 98% ee. Compatibility studies revealed that compartmentalisation of the catalysts is essential to achieve high yields and optical purities.
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