Journal
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Volume 64, Issue 3, Pages 287-293Publisher
ELSEVIER
DOI: 10.1016/j.ejpb.2006.06.009
Keywords
controlled release; PLGA; solubility; diffusion-reaction; kinetics
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We compare the rate of drug release through the degradation of 50:50 polylactic-co-glycolic acid polymer pellets, for six different drugs: Thiothixene, Haloperidol, Hydrochlorothiozide, Corticosterone, Ibuprofen, and Aspirin. Despite using the same polymer matrix and drug loading (20% by weight), we find that the rate of polymer degradation and the drug release profile differ significantly between the drugs. We conclude that the design of biodegradable polymeric drug carriers with high drug loadings must account for the effect of the drug on the polymer degradation and drug release rate. (c) 2006 Elsevier B.V. All rights reserved.
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