Journal
CEREBRAL CORTEX
Volume 16, Issue 11, Pages 1653-1661Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhj102
Keywords
blindness; human; magnetic resonance imaging; visual cortex/*physiology
Categories
Funding
- NINDS NIH HHS [R01 NS039538, R01NS047592, NS39538, R01 NS047592, P30 NS048056, NS037237, R01 NS037237, P30NS048056] Funding Source: Medline
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Multiple functional methods including functional magnetic resonance imaging, transcranial magnetic stimulation, and positron emission tomography have shown cortical reorganization in response to blindness. We investigated microanatomical correlates of this reorganization using diffusion tensor imaging and diffusion tensor tractography (DTT). Five early blind (EB) were compared with 7 normally sighted (NS) persons. DTT showed marked geniculocalcarine tract differences between EB and NS participants. All EB participants showed evidence of atrophy of the geniculocortical tracts. Connections between visual cortex and the orbital frontal and temporal cortices were relatively preserved in the EB group. Importantly, no additional tracts were found in any EB participant. Significant alterations of average diffusivity and relative anisotropy were found in the white matter (WM) of the occipital lobe in the EB group. These observations suggest that blindness leads to a reorganization of cerebral WM and plausibly support the hypothesis that visual cortex functionality in blindness is primarily mediated by corticocortical as opposed to thalamocortical connections.
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